several chronic health conditions in which the body does not clot properly, resulting in excessive or lengthy bleeding.
bleeding between infusions of factor product.
a person who has the gene for a condition, but does not necessarily display the symptoms.
proteins in the blood that act in sequence to stop bleeding and form a clot.
treatment that is infused to replace the body’s missing clotting proteins. It is made from plasma or recombinant products.
bleeding disorders identified by the missing clotting factor. They include factors I, II, V, VII, VIII, IX, X, XI, XII and XIII.
factor I deficiency:
a rare bleeding disorder caused by deficient or defective fibrinogen.
factor II deficiency:
an extremely rare bleeding disorder caused by a deficiency of prothrombin.
factor V deficiency:
a rare bleeding disorder caused by a deficiency of factor V protein.
factor VII deficiency:
the most common rare bleeding disorder, caused by a deficiency of factor VII protein. It is usually severe.
factor VIII deficiency:
A deficiency or absence of factor VIII. The most common form of hemophilia, also called “classic hemophilia.” Also called hemophilia A
factor IX deficiency:
a deficiency or absence of factor IX. Also called “Christmas disease” after the first family diagnosed with the condition. Also called hemophilia B.
factor X deficiency:
a rare bleeding disorder caused by a deficiency of factor X protein, which activates enzymes that help form a clot.
factor XI deficiency:
also called hemophilia C.
factor XII deficiency:
a rare bleeding disorder. Most people who have it do not experience bleeds.
factor XIII deficiency:
the rarest bleeding disorder, caused by the deficiency of
factor VIII protein:
which stabilizes the clot.
the time it takes for half the quantity of factor or factor product to be eliminated from blood plasma.
bleeding into a joint.
a physician specializing in disorders of the blood.
a factor VIII or IX level ranging from 5% to 40% of normal blood levels.
a factor VIII or IX level ranging from 1% to 5% of normal blood levels.
a factor VIII or IX level below 1% of normal blood levels.
hemophilia treatment centers (HTCs):
a group of federally funded hospitals that specialize in treating patients with bleeding disorders.
delivering clotting factor concentrate directly into a vein.
an antibody to infused clotting factor concentrates, making standard treatments ineffective.
a bleed into the brain.
a spending limit on insurance benefits. Once it is reached, the policy no longer provides coverage.
National Hemophilia Foundation:
a nonprofit organization founded in 1948 to serve the bleeding disorders community.
a device that delivers intravenous drugs. It is usually implanted under the skin in the chest.
a treatment regimen to prevent bleeds.
genetically engineered factor product made without human blood products, decreasing the risk of transmission of bloodborne infections.
a joint that has had repeated bleeds, or at least four bleeds within a six-month period.